The following citations represent the scholarly and/or creative works attributed to East Tennessee State University faculty in the Department of Surgery.
Articles
Activation of Cytosolic Phospholipase A2α in Resident Peritoneal Macrophages by Listeria Monocytogenes Involves Listeriolysin O and TLR2, Shahid Noor, Howard Goldfine, Dawn E. Tucker, Saritha Suram, Laurel L. Lenz, Shizuo Akira, Satoshi Uematsu, Milena Girotti, Joseph V. Bonventre, Kevin Breuel, David L. Williams, and Christina C. Leslie (2008)
Activation of Myocardial Phosphoinositide-3-Kinase p110α Ameliorates Cardiac Dysfunction and Improves Survival in Polymicrobial Sepsis, Chuanfu Li, Fang Hua, Tuanzhu Ha, Krishna Singh, Chen Lu, John Kalbfleisch, Kevin F. Breuel, Tiffany Ford, Race L. Kao, Ming Gao, Tammy R. Ozment, and David L. Williams (2012)
Avoided Heat-Related Mortality Through Climate Adaptation Strategies in Three US Cities, Brian Stone, Jason Vargo, Peng Liu, Dana Habeeb, Anthony DeLucia, Marcus Trail, Yongtao Hu, and Armistead Russell (2014)
Baicalein Inhibits IL-1β- and TNF-α-Induced Inflammatory Cytokine Production From Human Mast Cells via Regulation of the NF-κB Pathway, Chia Jung Hsieh, Kenton Hall, Tuanzhu Ha, Chuanfu Li, Guha Krishnaswamy, and David S. Chi (2007)
Candida Albicans β-Glucan Differentiates Human Monocytes Into a Specific Subset of Macrophages, Julia Leonhardt, Silke Große, Christian Marx, Fatina Siwczak, Sven Stengel, Tony Bruns, Reinhard Bauer, Michael Kiehntopf, David L. Williams, Zhao Qi Wang, Alexander S. Mosig, Sebastian Weis, Michael Bauer, and Regine Heller (2018)
Cellular and Molecular Mechanisms of Fungal β-(1→6)-Glucan in Macrophages, Ilka Noss, Tammy R. Ozment, Bridget M. Graves, Michael D. Kruppa, Peter J. Rice, and David L. Williams (2015)
Cell Wall N-Linked Mannoprotein Biosynthesis Requires Goa1p, a Putative Regulator of Mitochondrial Complex I in Candida Aabicans, Xiaodong She, Richard Calderone, Michael Kruppa, Douglas Lowman, David Williams, Lili Zhang, Ying Gao, Kasra Khamooshi, Weida Liu, and Dongmei Li (2016)
Coadministration of Adenoviral Vascular Endothelial Growth Factor and Angiopoietin-1 Enhances Vascularization and Reduces Ventricular Remodeling in the Infarcted Myocardium of Type 1 Diabetic Rats, Samson M. Samuel, Yuzo Akita, Debayon Paul, Mahesh Thirunavukkarasu, Lijun Zhan, Perumana R. Sudhakaran, Chuanfu Li, and Nilanjana Maulik (2010)
Dendritic Cell-Derived TSLP Negatively Regulates HIF-1α and IL-1β during Dectin-1 signaling, Matthew J. Elder, Steve J. Webster, Timothy J. Fitzmaurice, Aran S.D. Shaunak, Martin Steinmetz, Ronnie Chee, Ziad Mallat, E. Suzanne Cohen, David L. Williams, J. S. Hill Gaston, and Jane C. Goodall (2019)
Endothelial cell HSPA12B and Yes-Associated Protein Cooperatively Regulate Angiogenesis Following Myocardial Infarction, Min Fan, Kun Yang, Xiaohui Wang, Yana Wang, Fei Tu, Tuanzhu Ha, Li Liu, David L. Williams, and Chuanfu Li (2020)
Endothelial HSPA12B Exerts Protection Against Sepsis-Induced Severe Cardiomyopathy via Suppression of Adhesion Molecule Expression by miR-126, Xia Zhang, Xiaohui Wang, Min Fan, Fei Tu, Kun Yang, Tuanzhu Ha, Li Liu, John Kalbfleisch, David Williams, and Chuanfu Li (2020)
Enhanced Effects of Cigarette Smoke Extract on Inflammatory Cytokine Expression in IL-1β-Activated Human Mast Cells Were Inhibited by Baicalein via Regulation of the NF-κB Pathway, David S. Chi, Ta Chang Lin, Kenton Hall, Tuanzhu Ha, Chuanfu Li, Zong D. Wu, Thomas Soike, and Guha Krishnaswamy (2012)
Evaluation of Trained Immunity by β-1, 3 (D)-Glucan on Murine Monocytes in Vitro and Duration of Response in Vivo, Pablo Garcia-Valtanen, Ruth Marian Guzman-Genuino, David L. Williams, John D. Hayball, and Kerrilyn R. Diener (2017)
Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity, Rob J.W. Arts, Boris Novakovic, Rob ter Horst, Agostinho Carvalho, Siroon Bekkering, Ekta Lachmandas, Fernando Rodrigues, Ricardo Silvestre, Shih Chin Cheng, Shuang Yin Wang, Ehsan Habibi, Luís G. Gonçalves, Inês Mesquita, Cristina Cunha, Arjan van Laarhoven, Frank L. van de Veerdonk, David L. Williams, Jos van der Meer, Colin Logie, Luke A. O'Neill, Charles A. Dinarello, Niels P. Riksen, Reinout van Crevel, Clary Clish, Richard A. Notebaart, Leo A.B. Joosten, Hendrik G. Stunnenberg, and Ramnik J. Xavier (2016)
HSP27 Alleviates Cardiac Aging in Mice via a Mechanism Involving Antioxidation and Mitophagy Activation, Shenglan Lin, Yana Wang, Xiaojin Zhang, Qiuyue Kong, Chuanfu Li, Yuehua Li, Zhengnian Ding, and Li Liu (2016)
HSPA12A Attenuates Lipopolysaccharide-Induced Liver Injury Through Inhibiting Caspase-11-Mediated Hepatocyte Pyroptosis via PGC-1α-Dependent Acyloxyacyl Hydrolase Expression, Jiali Liu, Shuya Du, Qiuyue Kong, Xiaojin Zhang, Surong Jiang, Xiaofei Cao, Yuehua Li, Chuanfu Li, Huaqun Chen, Zhengnian Ding, and Li Liu (2020)
HSPA12A Is Required for Adipocyte Differentiation and Diet-Induced Obesity Through a Positive Feedback Regulation With PPARγ, Xiaojin Zhang, Xuan Chen, Tao qi, Qiuyue Kong, Hao Cheng, Xiaofei Cao, Yuehua Li, Chuanfu Li, Li Liu, and Zhengnian Ding (2019)
HSPA12A Unstabilizes CD147 to Inhibit Lactate Export and Migration in Human Renal Cell Carcinoma, Xinxu Min, Xiaojin Zhang, Yunfan Li, Xiaofei Cao, Hao Cheng, Yuehua Li, Chuanfu Li, Qiuyue Kong, Qian Mao, Peipei Peng, Yan Ni, Jingjin Li, Yulian Duan, Li Liu, and Zhengnian Ding (2020)
HSPA12B: A Novel Facilitator of Lung Tumor Growth, He Ma, Ting Lu, Xiaojin Zhang, Chuanfu Li, Jingwei Xiong, Lei Huang, Ping Liu, Yuehua Li, Li Liu, and Zhengnian Ding (2015)
HSPA12B Attenuated Acute Myocardial Ischemia/reperfusion Injury via Maintaining Endothelial Integrity in a PI3K/Akt/mTOR-dependent Mechanism, Qiuyue Kong, Leyang Dai, Yana Wang, Xiaojin Zhang, Chuanfu Li, Surong Jiang, Yuehua Li, Zhengnian Ding, and Li Liu (2016)
HSPA12B Promotes Functional Recovery After Ischaemic Stroke Through an eNOS-Dependent Mechanism, Yanlin Zhao, Chang Liu, Jiali Liu, Qiuyue Kong, Yu Mao, Hao Cheng, Nan Li, Xioajin Zhang, Chuanfu Li, Yuehua Li, Li Liu, and Zhengnian Ding (2018)
Identification and Characterization of a Novel Human Myeloid Inhibitory C-type Lectin-like Receptor (MICL) That Is Predominantly Expressed on Granulocytes and Monocytes, Andrew S.J. Marshall, Janet A. Willmen, Hsi Hsien Lin, David L. Williams, Siamon Gordon, and Gordon D. Brown (2004)
Lactate Promotes Macrophage HMGB1 Lactylation, Acetylation, and Exosomal Release in Polymicrobial Sepsis, Kun Yang, Min Fan, Xiaohui Wang, Jingjing Xu, Yana Wang, Fei Tu, P. S. Gill, Tuanzhu Ha, Li Liu, David L. Williams, and Chuanfu Li (2021)
Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling, Kun Yang, Jingjing Xu, Min Fan, Fei Tu, Xiaohui Wang, Tuanzhu Ha, David L. Williams, and Chuanfu Li (2020)
Loss of Sympathetic Nerves in Spleens From Patients With End Stage Sepsis, Donald B. Hoover, Thomas Christopher Brown, Madeleine K. Miller, John B. Schweitzer, and David L. Williams (2017)
Memory-Like Inflammatory Responses of Microglia to Rising Doses of LPS: Key Role of PI3Kγ, Trim Lajqi, Guang Ping Lang, Fabienne Haas, David L. Williams, Hannes Hudalla, Michael Bauer, Marco Groth, Reinhard Wetzker, and Reinhard Bauer (2019)
Memory-Like Responses of Brain Microglia Are Controlled by Developmental State and Pathogen Dose, Trim Lajqi, Milan Stojiljkovic, David L. Williams, Hannes Hudalla, Michael Bauer, Otto W. Witte, Reinhard Wetzker, Reinhard Bauer, and Christian Schmeer (2020)
Microbial Ligand Costimulation Drives Neutrophilic Steroid-Refractory Asthma, Sabelo Hadebe, Frank Kirstein, Kaat Fierens, Kong Chen, Rebecca A. Drummond, Simon Vautier, Sara Sajaniemi, Graeme Murray, David L. Williams, Pierre Redelinghuys, Todd A. Reinhart, Beth A.Fallert Junecko, Jay K. Kolls, Bart N. Lambrecht, Frank Brombacher, Gordon D. Brown, and Bernhard Ryffel (2015)
MicroRNA-214 Protects Against Hypoxia/Reoxygenation Induced Cell Damage and Myocardial Ischemia/Reperfusion Injury via Suppression of PTEN and Bim1 Expression, Xiaohui Wang, Tuanzhu Ha, Yuanping Hu, Chen Lu, Li Liu, Xia Zhang, Race Kao, John Kalbfleisch, David Williams, and Chuanfu Li (2016)
Myocyte-Specific Overexpressing HDAC4 Promotes Myocardial Ischemia/Reperfusion Injury, Ling Zhang, Hao Wang, Yu Zhao, Jianguo Wang, Patrycja M. Dubielecka, Shougang Zhuang, Gangjian Qin, Y. Eugene Chin, Race L. Kao, and Ting C. Zhao (2018)
New Insights Into the Structure of (1→3,1→6)-β-D-Glucan Side Chains in the Candida Glabrata Cell Wall, Douglas W. Lowman, Lara J. West, Daniel W. Bearden, Michael F. Wempe, Trevor D. Power, Harry E. Ensley, Ken Haynes, David L. Williams, and Michael D. Kruppa (2011)
Novel Role of Endothelial Derived Exosomal HSPA12B in Regulating Macrophage Inflammatory Responses in Polymicrobial Sepsis, Fei Tu, Xiaohui Wang, Xia Zhang, Tuanzhu Ha, Yana Wang, Min Fan, Kun Yang, P. Spencer Gill, Tammy R. Ozment, Yuan Dai, Li Liu, David L. Williams, and Chuanfu Li (2020)
Orally Delivered β-Glucans Aggravate Dextran Sulfate Sodium (DSS)-Induced Intestinal Inflammation, Sigrid E.M. Heinsbroek, David L. Williams, Olaf Welting, Sybren L. Meijer, Siamon Gordon, and Wouter J. de Jonge (2015)
Pathways Regulating Cytosolic Phospholipase a2 Activation and Eicosanoid Production in Macrophages by Candida Albicans, Saritha Suram, Todd A. Gangelhoff, Philip R. Taylor, Marcela Rosas, Gordon D. Brown, Joseph V. Bonventre, Shizuo Akira, Satoshi Uematsu, David L. Williams, Robert C. Murphy, and Christina C. Leslie (2010)
Phosphoinositide-3-kinase/akt - Dependent Signaling is Required for Maintenance of [Ca2+]I,ICa, and Ca2+ Transients in HL-1 Cardiomyocytes, Bridget M. Graves, Thomas Simerly, Chuanfu Li, David L. Williams, and Robert Wondergem (2012)
Regulation of Cytosolic Phospholipase a2 Activation and Cyclooxygenase 2 Expression in Macrophages by the β-Glucan Receptor, Saritha Suram, Gordon D. Brown, Moumita Ghosh, Siamon Gordon, Robyn Loper, Philip R. Taylor, Shizuo Akira, Satoshi Uematsu, David L. Williams, and Christina C. Leslie (2006)
Scavenger Receptor Class A Plays a Central Role in Mediating Mortality and the Development of the Pro-Inflammatory Phenotype in Polymicrobial Sepsis, Tammy R. Ozment, Tuanzhu Ha, Kevin F. Breuel, Tiffany R. Ford, Donald A. Ferguson, John Kalbfleisch, John B. Schweitzer, Jim L. Kelley, Chuanfu Li, and David L. Williams (2012)
Sensitivity of Air Pollution-Induced Premature Mortality to Precursor Emissions Under the Influence of Climate Change, Efthimios Tagaris, Kuo J. Liao, Anthony J. DeLucia, Leland Deck, Praveen Amar, and Armistead G. Russell (2010)
Simulation as a Disruptive Innovation in Advanced Practice Nursing Programs: A Report from a Qualitative Examination, Suzanne H. Campbell, Carla Nye, Susan H. Hébert, Candice Short, and Marie H. Thomas (2021)
The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus Fumigatus, Chad Steele, Rekha R. Rapaka, Allison Metz, Shannon M. Pop, David L. Williams, Siamon Gordon, Jay K. Kolls, and Gordon D. Brown (2005)
The Lipid Lowering Effect of Plant Sterol Ester Capsules in Hypercholesterolemic Subjects, Robert V. Acuff, David J. Cai, Zhi Ping Dong, and Doris Bell (2007)
The TLR9 ligand, CpG-ODN, Induces Protection Against Cerebral Ischemia/Reperfusion Injury via Activation of pi3k/Akt Signaling., Chen Lu, Tuanzhu Ha, Xiaohui Wang, L. Liu, Xia Zhang, Erinmarie Olson Kimbrough, Zhanxin Sha, Meijian Guan, John Schweitzer, John Kalbfleisch, David Williams, and Chuanfu Li (2014)
TIR/BB-Loop Mimetic AS-1 Attenuates Cardiac Ischemia/Reperfusion Injury via a Caveolae and Caveolin-3-Dependent Mechanism, Yuanping Hu, Meiling Zhang, Xin Shen, Guoliang Dai, Danyang Ren, Linli Que, Tuanzhu Ha, Chuanfu Li, Yong Xu, Wenzheng Ju, and Yuehua Li (2017)
TLR3 Mediates Repair and Regeneration of Damaged Neonatal Heart through Glycolysis Dependent YAP1 Regulated miR-152 Expression, Xiaohui Wang, Tuanzhu Ha, Li Liu, Yuanping Hu, Race Kao, John Kalbfleisch, David Williams, and Chuanfu Li (2018)
Trained Immunity or Tolerance: Opposing Functional Programs Induced in Human Monocytes After Engagement of Various Pattern Recognition Receptors, Daniela C. Ifrim, Jessica Quintin, Leo A.B. Joosten, Cor Jacobs, Trees Jansen, Liesbeth Jacobs, Neil A.R. Gow, David L. Williams, Jos W.M. Van Der Meer, and Mihai G. Netea (2014)
Tslp Production by Dendritic Cells Is Modulated by IL-1β and Components of the Endoplasmic Reticulum Stress Response, Matthew J. Elder, Steven J. Webster, David L. Williams, J. S.Hill Gaston, and Jane C. Goodall (2016)
Using Expanded Natural Killer Cells as Therapy for Invasive Aspergillosis, Win Mar Soe, Joan Hui Juan Lim, David L. Williams, Jessamine Geraldine Goh, Zhaohong Tan, Qi Hui Sam, Sanjay H. Chotirmall, Nur A’Tikah Binte Mohamed Ali, Soo Chin Lee, Ju Ee Seet, Sharada Ravikumar, and Louis Yi Ann Chai (2020)
β-Glucan Exacerbates Allergic Airway Responses to House Dust Mite Allergen, Sabelo Hadebe, Frank Kirstein, Kaat Fierens, Pierre Redelinghuys, Graeme I. Murray, David L. Williams, Bart N. Lambrecht, Frank Brombacher, and Gordon D. Brown (2016)
β-Glucan Size Controls Dectin-1-Mediated Immune Responses in Human Dendritic Cells by Regulating IL-1β Production, Matthew J. Elder, Steve J. Webster, Ronnie Chee, David L. Williams, J. S. Hill Gaston, and Jane C. Goodall (2017)
Β-(I→3)-D-Glucan Modulates Dna Binding of Nuclear Factors κB, at and IL-6 Leading to an Anti-Inflammatory Shift of the IL-I β/IL-I Receptor Antagonist Ratio, Juergen Luhm, Ulrich Langenkamp, Jenny Hensel, Christoph Frohn, Joerg M. Brand, Holger Hennig, Lothar Rink, Petra Koritke, Nadine Wittkopf, David L. Williams, and Antje Mueller (2006)
Conference Proceedings
Inhalation Toxicity of (1→3)-β-D-Glucan: Recent Advances, Birgitts Fogelmark, Margarets Sjöstrand, David Williams, and Ragnar Rylander (1997)
Overview of (1→3)-β-D-Glucan Immunobiology, David L. Williams (1997)
Oral Presentation
Promoting Health Education and Literacy in Rural Tennessee: The Go-Packs Pilot Project, Taylor Cox, Claire Gleadhill, William Seagrave, Coty Cooper, Alantis Hunt, Kelly Mitchell, Anthony DeLucia, and Randy Byington
Reviews
Lactate and Immunosuppression in Sepsis, Benjamin Nolt, Fei Tu, Xiaohui Wang, Tuanzhu Ha, Randi Winter, David L. Williams, and Chuanfu Li (2018)
