Document Type
Review
Publication Date
2-1-2018
Description
Serum lactate levels are traditionally interpreted as a marker of tissue hypoxia and often used clinically as an indicator of severity and outcome of sepsis/septic shock. Interestingly, recent studies involving the effects of tumor-derived lactate suggest that lactate itself may have an immunosuppressive effect in its local environment. This finding adds to the recent advances in immunometabolism that shed light on the importance of metabolism and metabolic intermediates in the regulation of innate immune and inflammatory responses in sepsis. In this article, we summarize recent studies, showing that the activation of immune cells requires aerobic glycolytic metabolism and that lactate produced by aerobic glycolysis may play an immunosuppressive role in sepsis.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Citation Information
Nolt, Benjamin; Tu, Fei; Wang, Xiaohui; Ha, Tuanzhu; Winter, Randi; Williams, David L.; and Li, Chuanfu. 2018. Lactate and Immunosuppression in Sepsis. Shock. Vol.49(2). 120-125. https://doi.org/10.1097/SHK.0000000000000958 PMID: 28767543 ISSN: 1073-2322
Copyright Statement
Copyright ß 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Shock Society. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.