Document Type
Article
Publication Date
4-9-2004
Description
Inhibitory and activatory C-type lectin-like receptors play an important role in immunity through the regulation of leukocytes. Here, we report the identification and characterization of a novel myeloid inhibitory C-type lectin-like receptor (MICL) whose expression is primarily restricted to granulocytes and monocytes. This receptor, which contains a single C-type lectin-like domain and a cytoplasmic immunoreceptor tyrosine-based inhibitory motif, is related to LOX-1 (lectin-like receptor for oxidized low density lipoprotein-1) and the β-glucan receptor (Dectin-1) and is variably spliced and highly N-glycosylated. We demonstrate that it preferentially associates with the signaling phosphatases SHP-1 and SHP-2, but not with SHIP. Novel chimeric analyses with a construct combining MICL and the β-glucan receptor show that MICL can inhibit cellular activation through its cytoplasmic immunoreceptor tyrosine-based inhibitory motff. These data suggest that MICL is a negative regulator of granulocyte and monocyte function.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Citation Information
Marshall, Andrew S.J.; Willmen, Janet A.; Lin, Hsi Hsien; Williams, David L.; Gordon, Siamon; and Brown, Gordon D.. 2004. Identification and Characterization of a Novel Human Myeloid Inhibitory C-type Lectin-like Receptor (MICL) That Is Predominantly Expressed on Granulocytes and Monocytes. Journal of Biological Chemistry. Vol.279(15). 14792-14802. https://doi.org/10.1074/jbc.M313127200 PMID: 14739280 ISSN: 0021-9258
Copyright Statement
© 2004 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.
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