Document Type
Article
Publication Date
4-2-2016
Description
β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Citation Information
Hadebe, Sabelo; Kirstein, Frank; Fierens, Kaat; Redelinghuys, Pierre; Murray, Graeme I.; Williams, David L.; Lambrecht, Bart N.; Brombacher, Frank; and Brown, Gordon D.. 2016. β-Glucan Exacerbates Allergic Airway Responses to House Dust Mite Allergen. Respiratory Research. Vol.17(1). https://doi.org/10.1186/s12931-016-0352-5 PMID: 27039089 ISSN: 1465-9921
Copyright Statement
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.