Histiocytic Lymphoma in the Mouse

Creator(s)

Charles H. Frith, Quillen-Dishner College of Medicine
T. Michael Davis, Quillen-Dishner College of Medicine
Laurence A. Zolotor, National Center for Toxicological Research
James W. Townsend, Quillen-Dishner College of Medicine

Document Type

Article

Publication Date

1-1-1980

Description

This investigation studied the occurrence, distribution and morphology; and the transplantation, ultrastructural and in vitro characteristics of histiocytic lymphoma in the BALB/c and C57BL/6 strains of mice. The disease was more common in aged females of both strains. The liver was the major organ involved in the males and the liver and uterus were commonly involved in the females. Subcutaneous transplants readily metastasized to the lungs. Ultrastructurally the neoplastic cells resembled histiocytes and did not contain microfilaments or a basement membrane. The results suggest that this neoplasm is histiocytic in origin.

Citation Information

Frith, Charles H.; Davis, T. Michael; Zolotor, Laurence A.; and Townsend, James W.. 1980. Histiocytic Lymphoma in the Mouse. Leukemia Research. Vol.4(6). 651-662. https://doi.org/10.1016/0145-2126(80)90076-4 PMID: 7009997 ISSN: 0145-2126