Turnover of Hela Ribosomal RNA: The Characterization of a Class of RNA in Hela Cytoplasm Derived From 28S RNA
Document Type
Article
Publication Date
9-1-1971
Description
A class of RNA in HeLa cytoplasm with a sedimentation value of 22S is described. This RNA is a true cytoplasmic component and is not an artifact of cell rupture or of the method of RNA preparation. The 22 S RNA sediments in a sucrose gradient with those ribosomal structures containing 28S ribosomal RNA (60S and 74S particles and polyribosomes). It has a base composition and methyl content similar to those of 28S RNA. The kinetics of formation of 22S suggest that it is not a direct product of transcription but is derived in vivo from "old" molecules of 28S RNA.
Citation Information
Nair, C. N.; and Knight, E.. 1971. Turnover of Hela Ribosomal RNA: The Characterization of a Class of RNA in Hela Cytoplasm Derived From 28S RNA. Journal of Cell Biology. Vol.50(3). 787-794. https://doi.org/10.1083/jcb.50.3.787 PMID: 5098866 ISSN: 0021-9525