Artifactual Hydropic Degeneration in Skin Biopsy Specimens Immersed in Saline: A Light and Electron Microscopic Study
Document Type
Article
Publication Date
1-1-1983
Description
An artifact consisting of hydropic degeneration of the basal cells and subepidermal bulla formation, is described in skin-punch biopsy specimens immersed in normal saline. The histologic appearance and ultrastructural features of this artifact are discussed. Proper handling of skin specimens intended for immunofluorescent studies is stressed. Similarities are noted between the histologic and ultrastructural findings of this artifact and of epidermolysis bullosa simplex and pathologic hydropic degeneration, as is seen in lupus erythematosus.
Citation Information
Inoshita, T.; and Youngberg, George A.. 1983. Artifactual Hydropic Degeneration in Skin Biopsy Specimens Immersed in Saline: A Light and Electron Microscopic Study. American Journal of Clinical Pathology. Vol.80(2). 206-209. https://doi.org/10.1093/ajcp/80.2.206 PMID: 6349324 ISSN: 0002-9173