Analysis and Kinetics of 2,4-Dinitrophenol Tissues by Capillary Gas Chromatography-Mass Spectrometry
Document Type
Article
Publication Date
1-1-1983
Description
Five groups of six ICR mice were orally dosed with 22.5 mg/kg 2,4-dinitrophenol. Groups were sacrificed at 1, 3, 6, 12, and 24 h post treatment, and serum, liver, and kidney tissues were collected for analysis of dinitrophenol content. Quantitation was performed via a capillary gas chromatography-mass spectrometry techniques after liquid-liquid extraction of biological specimens spiked with a trideuterated dinitrophenol internal standard. Concentration versus time data for each tissue were subjected to pharmacokinetic analysis. Similar two-compartment open models were found to characterize most phases of the disposition of this compound. The kidney appears to maintain a more persistent low concentration of 2,4-dinitrophenol.
Citation Information
Robert, T. A.; and Hagardorn, A. N.. 1983. Analysis and Kinetics of 2,4-Dinitrophenol Tissues by Capillary Gas Chromatography-Mass Spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications. Vol.276(C). 77-84. https://doi.org/10.1016/S0378-4347(00)85067-7 PMID: 6672026 ISSN: 0378-4347