The Macrophage Mannose Receptor Induces IL-17 in Response to Candida Albicans
Document Type
Article
Publication Date
4-23-2009
Description
The cytokine IL-17 controls neutrophil-mediated inflammatory responses. The pattern recognition receptor(s) that induce Th17 responses during infection, in the absence of artificial mitogenic stimulation with anti-CD3/anti-CD28 antibodies, remain obscure. We investigated the innate immune receptors and pathogen-associated molecular patterns involved in triggering Th17 responses during pathogen-specific host defense. The prototypic fungal pathogen Candida albicans was found to induce IL-17 more potently than Gram-negative bacteria. Candida mannan, but not zymosan, β-glucans, Toll-like receptor (TLR) agonists, or the NOD2 ligand MDP, induced IL-17 production in the absence of anti-CD3/anti-CD28 antibodies. Candida-induced IL-17 response was dependent on antigen-presenting cells and the macrophage mannose receptor (MR), demonstrating that Candida mannan is not simply a mitogenic stimulus. The TLR2/dectin-1 pathway, but not TLR4 or NOD2, amplified MR-induced IL-17 production. This study identifies the specific pattern recognition receptors that trigger the Th17 response induced by a human pathogen in the absence of mitogenic stimulation.
Citation Information
van de Veerdonk, Frank L.; Marijnissen, Renoud J.; Kullberg, Bart J.; Koenen, Hans J.; Cheng, Shih C.; Joosten, Irma; van den Berg, Wim B.; Williams, David L.; van der Meer, Jos W.M.; Joosten, Leo A.B.; and Netea, Mihai G.. 2009. The Macrophage Mannose Receptor Induces IL-17 in Response to Candida Albicans. Cell Host and Microbe. Vol.5(4). 329-340. https://doi.org/10.1016/j.chom.2009.02.006 PMID: 19380112 ISSN: 1931-3128