The Lack of Vitamin D Toxicity With Megadose of Daily Ergocalciferol (D2) Therapy: A Case Report and Literature Review
Document Type
Article
Publication Date
7-1-2009
Description
The maximum daily dose of vitamin D currently recommended is 2000 IU. Ergocalciferol (D2) 50,000 IU orally weekly for 8-12 weeks is often used to treat vitamin D deficient patients (25(OH) vitamin D <20 ng/mL). The lack of vitamin D toxicity after massive doses of ergocalciferol has yet to be reported in the literature. We report a case of a 56-year-old woman who received supratherapeutic doses of ergocalciferol (150,000 IU orally daily) for 28 years without toxicity. We discuss the possible mechanisms which may account for a lack of toxicity despite intake of massive daily doses of ergocalciferol in this patient.
Citation Information
Stephenson, David W.; and Peiris, Alan N.. 2009. The Lack of Vitamin D Toxicity With Megadose of Daily Ergocalciferol (D2) Therapy: A Case Report and Literature Review. Southern Medical Journal. Vol.102(7). 765-768. https://doi.org/10.1097/SMJ.0b013e3181a8d1e4 PMID: 19488004 ISSN: 0038-4348