Differential Virulence of Candida Glabrata Glycosylation Mutants

Creator(s)

Lara West, Imperial College London
Douglas W. Lowman, Quillen-Dishner College of Medicine
Héctor M. Mora-Montes, University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Sarah Grubb, Faculty of Medicine, Dentistry and Health
Craig Murdoch, Faculty of Medicine, Dentistry and Health
Martin H. Thornhill, Faculty of Medicine, Dentistry and Health
Neil A.R. Gow, University of Aberdeen School of Medicine, Medical Sciences and Nutrition
David Williams, Quillen-Dishner College of MedicineFollow
Ken Haynes, Imperial College London

Document Type

Article

Publication Date

7-26-2013

Description

Background: Candida glabrata virulence is poorly understood at the molecular level. Results: Inactivation of components of the C. glabrata glycosylation machinery results in changes in fungal mannan structure and altered virulence. Conclusion: Changes in C. glabrata cell wall architecture impact the host-pathogen interactions. Significance: Greater understanding of C. glabrata virulence will provide insights that can be adopted for development of novel diagnostic and therapeutic interventions.

Citation Information

West, Lara; Lowman, Douglas W.; Mora-Montes, Héctor M.; Grubb, Sarah; Murdoch, Craig; Thornhill, Martin H.; Gow, Neil A.R.; Williams, David; and Haynes, Ken. 2013. Differential Virulence of Candida Glabrata Glycosylation Mutants. Journal of Biological Chemistry. Vol.288(30). 22006-22018. https://doi.org/10.1074/jbc.M113.478743 PMID: 23720756 ISSN: 0021-9258