Diffuse Large B-Cell Lymphoma: A Metabolic Disorder?
Document Type
Article
Publication Date
12-2-2013
Description
Objective: Challenging differential diagnosis Background: B cell lymphoma constitutes 80-85% of cases of Non Hodgkin's lymphoma in the Untied States. Metabolic complications may arise from the disease itself or through its end organ involvement. Case Report: We describe a case of a diffuse large B cell lymphoma diagnosed by abdominal computed tomography after it initially presented as hypoglycemia not correctable by dextrose infusion that instead resulted in increased anion gap metabolic acidosis with elevated lactate levels. Conclusions: The case illustrates how lymphomas can present unusually with hypoglycemia and lactic acidosis, the latter being an ominous sign that can occur without liver involvement. In this regard, the case demonstrates the metabolic sequelae of lymphoma that should raise suspicion for an underlying process. This has implications for diagnosis, treatment, and patient survival. Attention should be paid especially in the primary care setting in order to minimize delays in diagnosis.
Citation Information
Tanios, Georges; Aranguren, Ines M.; Goldstein, Jack S.; and Patel, Chirag B.. 2013. Diffuse Large B-Cell Lymphoma: A Metabolic Disorder?. American Journal of Case Reports. Vol.14 518-525. https://doi.org/10.12659/AJCR.889580