Effect of Graded Aortic Occlusion on the Reticuloendothelial System
Document Type
Article
Publication Date
1-1-1987
Description
To evaluate the effect of graded aortic occlusion on the reticuloendothelial system (RES), 21 Sprague Dawley rats were subjected to fifteen (GI), thirty (GII), or sixty (GIII) minutes of distal aortic occlusion or to a sixty-minute sham operation (GIV) under general anesthesia. Chromium 51-labeled sheep red blood cells (SRBC) were injected twenty-four hours later, and SRBC half-life (T½) was measured as an index of RES function. Decreased RES function was (1) dependent upon the duration of clamping time, (2) most pronounced at sixty minutes’ clamping time, (3) characterized by a marked increase in SRBC half-life, along with a decreased radioactive uptake by the spleen and liver.
Citation Information
Vo, Nghia M.; Chi, David S.; and Stanton, Paul E.. 1987. Effect of Graded Aortic Occlusion on the Reticuloendothelial System. Vascular and Endovascular Surgery. Vol.21(6). 412-415. https://doi.org/10.1177/153857448702100606 ISSN: 1538-5744