Effect of Cisplatin on Hair Cell Morphology and Lateral Wall Na, K-ATPase Activity
Document Type
Article
Publication Date
1-1-1987
Description
The dose-response ototoxic effects of cisplatin were studied in guinea pigs. Loss of Preyer reflex and suppression of the N1 amplitude occurred in cisplatin-treated animals and was described as dose-related. Drug-induced hair cell damage, as observed with scanning electron microscopy, occurred sporadically throughout the turns of the cochlea and the incidence increased with dose. Na, K-ATPase activity in the lateral wall tissues was not significantly different between treatment groups. The results reported here indicate that cisplatin ototoxicity was dose-dependent, but was not directly related to Na,K-ATPase activity in the lateral wall.
Citation Information
Barron, Sarah E.; and Daigneault, Ernest A.. 1987. Effect of Cisplatin on Hair Cell Morphology and Lateral Wall Na, K-ATPase Activity. Hearing Research. Vol.26(2). 131-137. https://doi.org/10.1016/0378-5955(87)90104-3 PMID: 3032880 ISSN: 0378-5955