The Effects of Dietary α-Tocopherol and Polyunsaturated Fat on Modulating Ischemia-Reperfusion Injury
Document Type
Article
Publication Date
9-28-1999
Description
We investigated the effects of dietary α-tocopherol and polyunsaturated fatty acids (PUFA) on ischemia-reperfusion injury and cardiac lipid composition. Rats were fed corn oil (CO) diets either deficient (CO - E) or supplemented (CO + E) with RRR-α-tocopherol (100 IU kg-1 diet), or butter oil (BO) diets either deficient (BO - E) or supplemented (BO + E) with RRR-α-tocopherol (100 IU kg-1 diet). Intact rat hearts were subjected to ischemia before reperfusion. Dietary RRR-α-tocopherol supplementation contributed to recovery of aortic output, cardiac output and diastolic pressure after ischemia-reperfusion. In contrast, the type of dietary fat did not influence most measures of cardiac recovery. RRR-α-tocopherol levels in cardiac tissues and plasma were significantly higher for rats fed the BO + E diet than for rats fed the CO + E diet. In contrast to plasma, PUFA in cardiac tissues were maintained at a high level even when rats were fed BO containing diets. Our results suggest that dietary RRR-α-tocopherol, but not dietary PUFA levels, modulate oxidative damage to intact rat hearts during ischemia-reperfusion.
Citation Information
Huang, Annong; Kao, Race L.; Ma, Yanshan; and Stone, William L.. 1999. The Effects of Dietary α-Tocopherol and Polyunsaturated Fat on Modulating Ischemia-Reperfusion Injury. Journal of Nutritional and Environmental Medicine. Vol.9(3). 183-192. https://doi.org/10.1080/13590849961591 ISSN: 1359-0847