An Electrophysiological Study of 2-Hexanone and 2,5-Hexanedione Neurotoxicity in Rats
Document Type
Article
Publication Date
1-1-1984
Description
n-Hexane and its metabolites are neurotoxic to animals and man. Studies have revealed a progressive neuropathy which affects the distal regions of motor and sensory peripheral nerves. This paper describes efforts to determine whether 2-hexanone or 2,5-hexanedione is more neurotoxic to rats when given in drinking water. Our results show that 2,5-hexanedione is more neurotoxic than 2-hexanone and that it first affects the distal axon. Concentrations of 20 mM produced no effects after 3 weeks but 40 mM increased distal latency after 2 weeks.
Citation Information
Nachtman, Joseph P.; and Couri, Daniel. 1984. An Electrophysiological Study of 2-Hexanone and 2,5-Hexanedione Neurotoxicity in Rats. Toxicology Letters. Vol.23(2). 141-145. https://doi.org/10.1016/0378-4274(84)90118-8 PMID: 6506088 ISSN: 0378-4274