The Influence of Diet and Carnitine Supplementation on Plasma Carnitine, Cholesterol and Triglyceride in WHHL (Watanabe-Heritable Hyperlipidemic), Netherland Dwarf and New Zealand Rabbits (Oryctolagus Cuniculus)
Document Type
Article
Publication Date
1-1-1987
Description
1. 1. Plasma carnitine levels in the spontaneously (endogenously) hyperlipidemic Watanabe (WHHL) rabbit are approximately 2-fold higher (P < 0.001) than in normal rabbits of the New Zealand (NZ) or Netherland Dwarf (NDw) breeds. 2. 2. Plasma carnitine levels in WHHL (44±3 nmol/ml) can be approximated in NZ and NDw which are rendered exogenously hyperlipidemic by supplementation of the stock chow diet with cholesterol and peanut oil. 3. 3. The induction of endogenous hyperlipidemia in NZ by feeding a surcose casein rich diet results in a biphasic response of plasma carnitine (elevation followed by normalization). 4. 4. Plasma carnitine in WHHL is readily elevated by suplemental l-carnitine and the elevation is associated with a reduction in plasma triglyceride which shows differences in individual response time; plasma cholesterol is unaffected by supplemental l-carnitine.
Citation Information
Bell, Frank P.; Raymond, Thomas L.; and Patnode, Catherine L.. 1987. The Influence of Diet and Carnitine Supplementation on Plasma Carnitine, Cholesterol and Triglyceride in WHHL (Watanabe-Heritable Hyperlipidemic), Netherland Dwarf and New Zealand Rabbits (Oryctolagus Cuniculus). Comparative Biochemistry and Physiology -- Part B: Biochemistry and. Vol.87(3). 587-591. https://doi.org/10.1016/0305-0491(87)90056-3 PMID: 3621915 ISSN: 0305-0491