The Effect of Oral L-Carnitine on Lipoprotein Composition in the Watanabe Heritable Hyperlipidemic Rabbit (Oryctolagus Cuniculus)
Document Type
Article
Publication Date
1-1-1987
Description
1. 1. We have recently reported the ability of orally administered l-carnitine to lower plasma triglyceride in the Watanabe Heritable Hyperlipidemic Rabbit (WHHL), an animal model of familial hyperlipoproteinemia. 2. 2. In the present studies we examined the effect of l-carnitine administration upon individual lipoprotein subfractions in this animal model. 3. 3. Carnitine feecling resulted in a reduction in very low density lipoproteins (VLDL) and high density lipoprotein (HDL). 4. 4. Compositional analysis revealed a reduction in core triglyceride content with a concomitant increase in protein and phospholipid in VLDL and low density lipoproteins (LDL). 5. 5. Conversely, electrophoretic mobility and apolipoprotein composition were unchanged with l- carnitine. 6. 6. These results further demonstrate the ability of l-carnitine to modulate lipoprotein lipid composition in this animal model of familial hyperlipoproteinemia.
Citation Information
Raymond, Thomas L.; Reynolds, Scott A.; Swanson, Julia A.; Patnode, Catherine A.; and Bell, Frank P.. 1987. The Effect of Oral L-Carnitine on Lipoprotein Composition in the Watanabe Heritable Hyperlipidemic Rabbit (Oryctolagus Cuniculus). Comparative Biochemistry and Physiology -- Part A: Physiology. Vol.88(3). 503-506. https://doi.org/10.1016/0300-9629(87)90071-5 PMID: 2892624 ISSN: 0300-9629