The Effects of Ascorbic Acid on Diphtheria Toxin and Intoxicated Hela Cells
Document Type
Article
Publication Date
1-1-1976
Description
Ascorbic acid (vitamin C) prevented diphtheria toxin from inhibiting the incorporation of [U-14C]-alanine into trichloroacetic acid precipitable material in HeLa cells. Ascorbic acid did not exhibit an effect on the adenosine diphosphate-ribosylation of amino acyl transferase II nor did it separate fragment A from fragment B in “nicked” toxin. A non-specific reducing agent, para-methylaminophenol sulfate, exhibited an effect on HeLa cells very similar to the results of ascorbic acid. Citric acid, a tricarboxylic acid, had no effect on HeLa cell.
Citation Information
Clark, Charles E.; and Smith, Timothy J.. 1976. The Effects of Ascorbic Acid on Diphtheria Toxin and Intoxicated Hela Cells. Journal of Nutritional Science and Vitaminology. Vol.22(4). 313-319. https://doi.org/10.3177/jnsv.22.313 PMID: 189004 ISSN: 0301-4800