The Many Roles of CD40 in Cell-Mediated Inflammatory Responses

Document Type

Review

Publication Date

1-1-1996

Description

In addition to B cells, CD40 is expressed by a variety of cells including dendritic cells, monocytes, fibroblasts and vascular endothelial cells. As discussed here by Robert Stout and Jill Suttles, CD40-CD40 ligand interactions can influence many aspects of T-cell-mediated inflammatory responses, such as cell extravasation, production of inflammatory and chemotactic cytokines, as well as activation of macrophage effector functions.

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