Absence of Sodium Appetite in Cyclophosphamide and DOCA Treated House Mice

Creator(s)

J. N. Pasley, Quillen-Dishner College of Medicine
T. I. Koike, Quillen-Dishner College of Medicine
H. L. Neldon, Quillen-Dishner College of Medicine

Document Type

Article

Publication Date

1-1-1977

Description

Intraperitoneal administration of cyclophosphamide 100 mg/kg and 200 mg/kg significantly lowered plasma sodium and significantly increased plasma potassium but did not result in saline preference in a strain of wild-derived house mice given a choice between water and saline (0.15M) to drink. Deoxycorticosterone acetate treatment in dosages up to 1.5 mg for four days also failed to increase salt intake. The data suggest a possible absence of a sodium appetite mechanism in this species.

Citation Information

Pasley, J. N.; Koike, T. I.; and Neldon, H. L.. 1977. Absence of Sodium Appetite in Cyclophosphamide and DOCA Treated House Mice. Pharmacology, Biochemistry and Behavior. Vol.6(3). 265-267. https://doi.org/10.1016/0091-3057(77)90024-7 PMID: 857252 ISSN: 0091-3057