The Effect of Δ-9-Tetrahydrocannabinol on Herpes Simplex Virus Replication

Creator(s)

R. D. Blevins, East Tennessee State University
M. P. Dumic, East Tennessee State University

Document Type

Article

Publication Date

1-1-1980

Description

Both herpes simplex virus type I (HSV-I) and herpes simplex virus type 2 (HSV-2) failed, in an identical fashion to replicate and produce extensive c.p.e. in human cell monolayer cultures which were exposed (8 h before infection, at infection, or 8 h p.i.) to various concentrations of Δ-9-tetrahydrocannabinol. Similar results were obtained with a plaque assay utilizing confluent monkey cells. Possible mechanisms for this antiviral activity are discussed.

Citation Information

Blevins, R. D.; and Dumic, M. P.. 1980. The Effect of Δ-9-Tetrahydrocannabinol on Herpes Simplex Virus Replication. Journal of General Virology. Vol.49(2). 427-431. https://doi.org/10.1099/0022-1317-49-2-427 PMID: 6255077 ISSN: 0022-1317