The Effect of Δ-9-Tetrahydrocannabinol on Herpes Simplex Virus Replication

Document Type

Article

Publication Date

1-1-1980

Description

Both herpes simplex virus type I (HSV-I) and herpes simplex virus type 2 (HSV-2) failed, in an identical fashion to replicate and produce extensive c.p.e. in human cell monolayer cultures which were exposed (8 h before infection, at infection, or 8 h p.i.) to various concentrations of Δ-9-tetrahydrocannabinol. Similar results were obtained with a plaque assay utilizing confluent monkey cells. Possible mechanisms for this antiviral activity are discussed.

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