Resolution of the Neutropenia of Felty's Syndrome by Longterm Administration of Recombinant Granulocyte Colony Stimulating Factor
Document Type
Article
Publication Date
4-24-1996
Description
Felty's syndrome is characterized by neutropenia, splenomegaly, and recurrent infection in patients with rheumatoid arthritis. We Used recombinant granulocyte colony stimulating factor (rGCSF) in a patient with Felty's syndrome and recurrent sepsis. rGCSF induced a statistically significant increase in the patient's absolute neutrophil and total white blood cell counts. During 14 months of followup taking rGCSF, disseminated varicella zoster was the only infectious complication. Except mild thrombocytopenia and a transient flare of arthritis, no serious adverse effects occurred. rGCSF may be a safe and effective therapy for Felty's syndrome in selected patients.
Citation Information
Krishnaswamy, Guha; Odem, Caroll; Chi, David S.; Kalbfleisch, John; Baker, Neal; and Smith, John Kelly. 1996. Resolution of the Neutropenia of Felty's Syndrome by Longterm Administration of Recombinant Granulocyte Colony Stimulating Factor. Journal of Rheumatology. Vol.23(4). 763-765. https://pubmed.ncbi.nlm.nih.gov/8730142/ PMID: 8730142 ISSN: 0315-162X