Mechanisms of Formation of Novel Guanine-Guanine Cross-Links as Major End Products during One-Electron Oxidation of Guanine Derivatives
Faculty Mentor
Dr. Marina Roginskaya
Mentor Home Department
Chemistry
Short Abstract
Previous research discovered a novel type of products of G• dimerization, D1 and D2, formed as a result of one-electron oxidation of G derivatives. However, the mechanism of this dimerization remains elusive. It remains unclear which intermediate of G (G(N1-H) or G(N2-H)) participates in the formation of D1 and D2. By methylating the N1 nitrogen, it was demonstrated using HPLC and 1H-NMR analysis that hydrogens at the N2 position are absolutely required for D1 and D2 analogs to be produced.
Category
Science and Technology
Start Date
24-4-2023 10:45 AM
End Date
24-4-2023 11:00 AM
Location
D.P. Culp Center Room 219
Mechanisms of Formation of Novel Guanine-Guanine Cross-Links as Major End Products during One-Electron Oxidation of Guanine Derivatives
D.P. Culp Center Room 219
Previous research discovered a novel type of products of G• dimerization, D1 and D2, formed as a result of one-electron oxidation of G derivatives. However, the mechanism of this dimerization remains elusive. It remains unclear which intermediate of G (G(N1-H) or G(N2-H)) participates in the formation of D1 and D2. By methylating the N1 nitrogen, it was demonstrated using HPLC and 1H-NMR analysis that hydrogens at the N2 position are absolutely required for D1 and D2 analogs to be produced.