Honors Program
Honors in Chemistry
Date of Award
5-2021
Thesis Professor(s)
Cerrone Foster
Thesis Professor Department
Biological Sciences
Thesis Reader(s)
Marina Roginskaya
Abstract
Evidence in animal studies show that estrogen in women is cardioprotective, but discrepancies remain between clinical and animal studies regarding progression of cardiovascular disease after menopause. Cardiac fibrosis, the build-up of type I and III collagen fibers, is a staple of cardiac remodeling. The goal of this study was to examine the effects of long-term estrogen loss in the heart; this study includes two time points (1-month and 5-month) post-ovariectomy. Mice were randomly selected for 4 treatment groups: SHAM, Ovariectomy (OVX), Isoproterenol (ISO) (a β-adrenergic agonist used to mimic chronic sympathetic stimulation) and OVX+ISO. Mice were infused with either Saline (SHAM, OVX) or ISO (400 µg/kg/hr) via a mini osmotic pump for 7 days at 1- and 5-month post OVX. Cardiac fibrosis was examined using Mason’s Trichrome Staining with the hypothesis that fibrosis would present higher in OVX and ISO mice, compared to SHAM. Significance was not found between groups.
Publisher
East Tennessee State University
Document Type
Honors Thesis - Withheld
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Recommended Citation
WiseCarver, Samuel, "The Effects of Timing and Long-Term Estrogen Deficiency on Cardiac Fibrosis Following Chronic Sympathetic Stimulation" (2021). Undergraduate Honors Theses. Paper 836. https://dc.etsu.edu/honors/836
Copyright
Copyright by the authors.
Included in
Amino Acids, Peptides, and Proteins Commons, Biology Commons, Cardiovascular System Commons
