Microfluidics-Based Separation of Actinium-225 From Radium-225 for Medical Applications
Document Type
Article
Publication Date
8-13-2019
Description
Separation of 225Ra (t1/2 = 15 d) from its daughter isotope 225Ac (t1/2 = 10 d) is necessary to obtain pure 225Ac for cancer alpha-therapy. In this study, microscale separation of 225Ra from its daughter 225Ac using BioRad AG50X4 cation exchange resin was achieved with good reproducibility across microdevices, and ≥90% purity was achieved for 225Ac, which is comparable to conventional chromatography. These results indicate the potential for greater use of microfluidics for biomedical radiochemistry. The modularity of the system and its compatibility with different resins allows for quick and easy adaptation to the various needs of a separation campaign.
Citation Information
Davern, Sandra; O’Neil, David; Hallikainen, Hannah; O’Neil, Kathleen; Allman, Steve; Millet, Larry; Retterer, Scott; Doktycz, Mitchel; Standaert, Robert; Boll, Rose; Van Cleve, Shelley; DePaoli, David; and Mirzadeh, Saed. 2019. Microfluidics-Based Separation of Actinium-225 From Radium-225 for Medical Applications. Separation Science and Technology (Philadelphia). Vol.54(12). 1994-2002. https://doi.org/10.1080/01496395.2019.1614956 ISSN: 0149-6395