Sex Differences in Initiation and Expression of Methylplhenidate Sensitization in Adolescent Rats: Analysis of Accumbal and Striatal BDNF

Document Type

Presentation

Publication Date

5-4-2012

Description

This study analyzed locomotor sensitization to methylphenidate (MPH, Trade name: Ritalin) in adolescent male and female rats. Females, but not males, demonstrated locomotor sensitization. Interestingly, females given MPH demonstrated a significant decrease of brain derived neurotrophic factor (BDNF) in the striatum, whereas males demonstrated an increase in this same brain area.

Location

Chicago, IL

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