Sex Differences in Initiation and Expression of Methylplhenidate Sensitization in Adolescent Rats: Analysis of Accumbal and Striatal BDNF
Document Type
Presentation
Publication Date
5-4-2012
Description
This study analyzed locomotor sensitization to methylphenidate (MPH, Trade name: Ritalin) in adolescent male and female rats. Females, but not males, demonstrated locomotor sensitization. Interestingly, females given MPH demonstrated a significant decrease of brain derived neurotrophic factor (BDNF) in the striatum, whereas males demonstrated an increase in this same brain area.
Location
Chicago, IL
Citation Information
Roeding, Ross L.; Perna, Marla K.; and Brown, Russell W.. 2012. Sex Differences in Initiation and Expression of Methylplhenidate Sensitization in Adolescent Rats: Analysis of Accumbal and Striatal BDNF. Midwestern Psychological Association Conference, Chicago, IL. https://www.midwesternpsych.org/Resources/Programs/Program2012.pdf