Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection
Document Type
Article
Publication Date
6-16-2020
Description
The dichotomy between type 1 and 2 conventional DCs under steady-state conditions is well defined. Bosteels et al. demonstrate that, upon inflammation, cDC2s acquire a hybrid inf-cDC2 phenotype, sharing phenotype, gene expression, and function with cDC1s and monocyte-derived cells, to optimally boost CD4 and CD8 immunity via Fc receptors.
Citation Information
Bosteels, Cedric; Neyt, Katrijn; Vanheerswynghels, Manon; van Helden, Mary J.; Sichien, Dorine; Debeuf, Nincy; De Prijck, Sofie; Bosteels, Victor; Vandamme, Niels; Martens, Liesbet; Saeys, Yvan; Louagie, Els; Lesage, Manon; Williams, David L.; Tang, Shiau Choot; Mayer, Johannes U.; Ronchese, Franca; Scott, Charlotte L.; Hammad, Hamida; Guilliams, Martin; and Lambrecht, Bart N.. 2020. Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection. Immunity. Vol.52(6). 1039-1056.e9. https://doi.org/10.1016/j.immuni.2020.04.005 PMID: 32392463 ISSN: 1074-7613