30s Ribosomal Subunit Assembly Is a Target for Inhibition by Aminoglycosides in Escherichia Coli
Document Type
Article
Publication Date
5-2-2002
Description
The aminoglycosides paromomycin and neomycin were examined in Escherichia coli cells for an inhibitory effect on 30S ribosomal subunit assembly. Both compounds inhibited the growth rate, viable cell number, and protein synthesis rate with similar 50% inhibitory concentrations. Each drug also showed a concentration-dependent inhibition of 30S subunit formation. The inhibitory effect on 30S particle formation was approximately equivalent to the inhibitory effect on translation for these antibiotics.
Citation Information
Mehta, Roopal; and Champney, W. Scott. 2002. 30s Ribosomal Subunit Assembly Is a Target for Inhibition by Aminoglycosides in Escherichia Coli. Antimicrobial Agents and Chemotherapy. Vol.46(5). 1546-1549. https://doi.org/10.1128/AAC.46.5.1546-1549.2002 PMID: 11959595 ISSN: 0066-4804