Left Vagal Stimulation Induces Dynorphin Release and Suppresses Substance P Release From the Rat Thoracic Spinal Cord During Cardiac Ischemia
Document Type
Article
Publication Date
12-1-2004
Description
Electrostimulatory forms of therapy can reduce angina that arises from activation of cardiac nociceptive afferent fibers during transient ischemia. This study sought to determine the effects of electrical stimulation of left thoracic vagal afferents (C8-T1 level) on the release of putative nociceptive [substance P (SP)] and analgesic [dynorphin (Dyn)] peptides in the dorsal horn at the T4 spinal level during coronary artery occlusion in urethane-anesthetized Sprague-Dawley rats. Release of Dyn and SP was measured by using antibody-coated microprobes. While Dyn and SP had a basal release, occlusion of the left anterior descending coronary artery only affected SP release, causing an increase from lamina I-VII. Left vagal stimulation increased Dyn release, inhibited basal SP release, and blunted the coronary artery occlusion-induced release of SP. Dyn release reflected activation of descending pathways in the thoracic spinal cord, because vagal afferent stimulation still increased the release of Dyn after bilateral dorsal rhizotomy of T2-T5. These results indicate that electrostimulatory therapy, using vagal afferent excitation, may induce analgesia, in part, via inhibition of the release of SP in the spinal cord, possibly through a Dyn-mediated neuronal interaction.
Citation Information
Hua, Fang; Ardell, Jeffrey L.; and Williams, Carole A.. 2004. Left Vagal Stimulation Induces Dynorphin Release and Suppresses Substance P Release From the Rat Thoracic Spinal Cord During Cardiac Ischemia. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. Vol.287(6 56-6). https://doi.org/10.1152/ajpregu.00251.2004 PMID: 15297264 ISSN: 0363-6119