Abnormal B-Cell Responses to Chemokines, Disturbed Plasma Cell Localization, and Distorted Immune Tissue Architecture in Rgs1-/- Mice
Document Type
Article
Publication Date
7-1-2004
Description
Normal lymphoid tissue development and function depend upon chemokine-directed cell migration. Since chemokines signal through heterotrimeric G-protein-coupled receptors, RGS proteins, which act as GTPase-activating proteins for Gα subunits, likely fine tune the cellular responses to chemokines. Here we show that Rgs1-/- mice possess B cells that respond excessively and desensitize improperly to the chemokines CXCL12 and CXCL13. Many of the B-cell follicles in the spleens of Rgs1 -/- mice have germinal centers even in the absence of immune stimulation. Furthermore, immunization of these mice leads to exaggerated germinal center formation; partial disruption of the normal architecture of the spleen and Peyer's patches; and abnormal trafficking of immunoglobulin-secreting cells. These results reveal the importance of a regulatory mechanism that limits and desensitizes chemokine receptor signaling.
Citation Information
Moratz, Chantal; Hayman, J. Russell; Gu, Hua; and Kehrl, John H.. 2004. Abnormal B-Cell Responses to Chemokines, Disturbed Plasma Cell Localization, and Distorted Immune Tissue Architecture in Rgs1-/- Mice. Molecular and Cellular Biology. Vol.24(13). 5767-5775. https://doi.org/10.1128/MCB.24.13.5767-5775.2004 PMID: 15199133 ISSN: 0270-7306