Presence of Monoclonal Free Light Chains in the Serum Predicts Risk of Progression in Monoclonal Gammopathy of Undetermined Significance
Document Type
Article
Publication Date
11-1-2004
Description
We hypothesized that the presence of monoclonal free light chains (FLC) in the serum of patients with monoclonal gammopathy of undetermined significance (MGUS) is a marker of clonal evolution and a risk factor for progression. Forty-seven patients with MGUS and documented progression to myeloma or related malignancy were compared with 50 age- and gender-matched patients with MGUS and no evidence of progression after 5 or more years of follow-up. The presence of an abnormal kappa/lambda FLC ratio in the serum was associated with a higher risk of MGUS progression (relative risk 2.5; 95% confidence interval: 1.6-4.0; P < 0.001).
Citation Information
Rajkumar, S. Vincent; Kyle, Robert A.; Therneau, Terry M.; Clark, Raynell J.; Bradwell, Arthur R.; Melton, L. Joseph; Larson, Dirk R.; Plevak, Matthew F.; and Katzmann, Jerry. 2004. Presence of Monoclonal Free Light Chains in the Serum Predicts Risk of Progression in Monoclonal Gammopathy of Undetermined Significance. British Journal of Haematology. Vol.127(3). 308-310. https://doi.org/10.1111/j.1365-2141.2004.05169.x PMID: 15491291 ISSN: 0007-1048