Title
CRP After 2004
Document Type
Review
Publication Date
1-1-2005
Description
C-reactive protein (CRP) that has been conserved throughout evolution is a host-defense molecule. Its attraction towards phosphocholine-ligands, such as modified low-density lipoprotein, and apoptotic cells leads to the "masking" of these substances that have the capabilities to otherwise engage in deleterious activities. Complement activation by CRP complexes and the modulation by CRP of complement activation by its ligands add up to its beneficial effects. In the presence of CRP, production of membrane-damaging last product of the complement pathway is arrested. CRP is currently serving as an indicator of cardiovascular diseases, but to pinpoint the role of CRP in atherosclerosis, a drug that can lower cholesterol levels, but not the CRP levels, is needed for experimentation.
Citation Information
Agrawal, Alok. 2005. CRP After 2004. Molecular Immunology. Vol.42(8). 927-930. https://doi.org/10.1016/j.molimm.2004.09.028 PMID: 15829284 ISSN: 0161-5890