In Vivo Rescue of Defective Memory CD8+ T Cells by Cognate Helper T Cells
Document Type
Article
Publication Date
10-1-2005
Description
The magnitude and efficacy of CD8+ T cell memory may notably regress, especially if immune induction occurs in the absence of adequate CD4+ help. This report demonstrates that this CD8+ memory malfunction could be remedied if a source of cognate antigen-recognizing helper cells were provided during recall. The inability of adoptive transfer of memory SIINFEKL-specific CD8 cells to reject tumors was overcome if recipients were primed for ovalbumin-specific helper cell responses. Additionally, animals primed for a SIINFEKL-specific memory response and incapable of rejecting the tumor could regain protective immunity if given helper cells. This pattern of CD8+ T cell functional rescue or reprogramming by helper cell transfer was replicated using a Herpes simplex virus antiviral immunity system. Our results could mean that therapeutic vaccine approaches could be designed to compensate situations that have defective CD8+ T cell function.
Citation Information
Kumaraguru, Udayasankar; Banerjee, Kaustuv; and Rouse, Barry T.. 2005. In Vivo Rescue of Defective Memory CD8+ T Cells by Cognate Helper T Cells. Journal of Leukocyte Biology. Vol.78(4). 879-887. https://doi.org/10.1189/jlb.0105007 PMID: 16081600 ISSN: 0741-5400