Modulation of the Phosphoinositide 3-Kinase Signaling Pathway Alters Host Response to Sepsis, Inflammation, and Ischemia/Reperfusion Injury
Document Type
Review
Publication Date
5-1-2006
Description
The phosphoinositide 3-kinases (PI3Ks) are a conserved family of signal transduction enzymes that are involved in regulating cellular activation, inflammatory responses, chemotaxis, and apoptosis. We have discovered that a carbohydrate ligand, glucan, will stimulate the endogenous PI3K/Akt signaling pathway. This article reviews the current data on the role of the PI3K/Akt signaling pathway as a negative feedback mechanism or compensatory regulator of septic and inflammatory responses. Of greater importance, the data reviewed in this article suggest that modulation of the PI3K/ Akt signaling pathway can reduce the morbidity and mortality associated with septic and I/R injury. Thus, manipulation of the endogenous PI3K/Akt signaling pathway may represent a new and novel therapeutic approach to management of important diseases.
Citation Information
Williams, David; Ozment-Skelton, Tammy; and Li, Chuanfu. 2006. Modulation of the Phosphoinositide 3-Kinase Signaling Pathway Alters Host Response to Sepsis, Inflammation, and Ischemia/Reperfusion Injury. Shock. Vol.25(5). 432-439. https://doi.org/10.1097/01.shk.0000209542.76305.55 PMID: 16680006 ISSN: 1073-2322