Safrole Oxide Induces Apoptosis by Activating Caspase-3, -8, and -9 in a549 Human Lung Cancer Cells

Creator(s)

Ai Du, Shandong University
Bao Xiang Zhao, Shandong University
De Ling Yin, East Tennessee State University
Shang Li Zhang, Shandong University
Jun Ying Miao, Shandong University

Document Type

Article

Publication Date

1-1-2006

Description

Previously we found that 3,4-(methylenedioxy)-1-(2′,3′- epoxypropyl)-benzene (safrole oxide) induced a typical apoptosis in A549 human lung cancer cells. In this study, we further investigated which caspases were activated by safrole oxide during the apoptosis. The data showed that the activity of caspase-3, -8, and -9 was significantly enhanced by the compound, which suggested that safrole oxide might be used as a caspase promoter to initiate lung cancer cell apoptosis.

Citation Information

Du, Ai; Zhao, Bao Xiang; Yin, De Ling; Zhang, Shang Li; and Miao, Jun Ying. 2006. Safrole Oxide Induces Apoptosis by Activating Caspase-3, -8, and -9 in a549 Human Lung Cancer Cells. Bioorganic and Medicinal Chemistry Letters. Vol.16(1). 81-83. https://doi.org/10.1016/j.bmcl.2005.09.050 PMID: 16242324 ISSN: 0960-894X