Proposed Animal Model of Severe Parkinson's Disease: Neonatal 6-Hydroxydopamine Lesion of Dopaminergic Innervation of Striatum
Document Type
Conference Proceeding
Publication Date
1-1-2006
Description
Rats lesioned shortly after birth with 6-hydroxydopamine are posed as a near-ideal model of severe Parkinson's disease, because of the non-lethality of the procedure, near-total destruction of nigrostriatal dopaminergic fibers, near-total dopamine (DA)-denervation of striatum, reproducibility of effect, and relative absence of overt behavioral effects - there is no aphasia, no adipsia, and no change in motor activity. In vivo microdialysis findings reinforce the utility of the animal model, clearly demonstrating L-DOPA beneficial actions without an increase in hydroxyl radical production.
Citation Information
Kostrzewa, R.; Kostrzewa, J. P.; Brus, R.; Kostrzewa, R. A.; and Nowak, P.. 2006. Proposed Animal Model of Severe Parkinson's Disease: Neonatal 6-Hydroxydopamine Lesion of Dopaminergic Innervation of Striatum. Journal of Neural Transmission, Supplement. (70). 277-279. https://doi.org/10.1007/978-3-211-45295-0_43 PMID: 17017542 ISSN: 0303-6995