Farnesylated Lamins, Progeroid Syndromes and Farnesyl Transferase Inhibitors
Document Type
Article
Publication Date
8-15-2006
Description
Three mammalian nuclear lamin proteins, lamin B1, lamin B2 and the lamin A precursor, prelamin A, undergo canonical farnesylation and processing at CAAX motifs. In the case of prelamin A, there is an additional farnesylation-dependent endoproteolysis, which is defective in two congenital diseases: Hutchinson-Gilford progeria (HGPS) and restrictive dermopathy (RD). These two diseases arise respectively from defects in the prelamin A substrate and the enzyme (ZmpSte24) that processes it. Recent work has shed light on the roles of the lamin proteins and the enzymes involved in their farnesylation-dependent maturation. Other experimental work, including mouse model studies, have examined the possibility that farnesyl transferase inhibitors can represent effective treatment for HGPS. However, there are concerns about their use for this purpose given the potential for alternative prenylation pathways.
Citation Information
Rusiñol, Antonio; and Sinensky, Michael S.. 2006. Farnesylated Lamins, Progeroid Syndromes and Farnesyl Transferase Inhibitors. Journal of Cell Science. Vol.119(16). 3265-3272. https://doi.org/10.1242/jcs.03156 PMID: 16899817 ISSN: 0021-9533