Expression of Complement System Regulatory Molecules in the Endometrium of Normal Ovulatory and Hyperstimulated Women Correlate With Menstrual Cycle Phase
Document Type
Article
Publication Date
9-1-2006
Description
The present study describes the temporal expression of complement regulatory molecules membrane cofactor protein (MCP), decay accelerating factor (DAF), CR1, and CD59 in the human endometrium throughout the normal menstrual cycle and in patients submitted to ovarian hyperstimulation. During its proliferative phase, the endometrium expresses MCP, with increased expression during the secretory phase. Phase-dependent expression also was observed for DAF and CD59, mainly in the secretory phase. Expression of CR1 was not detected. These results suggest the presence of complement system activity during the menstrual cycle, with greater expression of regulatory molecules during the secretory phase to protect the epithelial integrity of human endometrium.
Citation Information
Nogawa Fonzar-Marana, Rosana; Ferriani, Rui Alberto; Gomes Soares, Sandro; Cavalcante-Neto, Florêncio Figueiredo; Teixeira, José Eduardo; and Barbosa, José Elpídio. 2006. Expression of Complement System Regulatory Molecules in the Endometrium of Normal Ovulatory and Hyperstimulated Women Correlate With Menstrual Cycle Phase. Fertility and Sterility. Vol.86(3). 758-761. https://doi.org/10.1016/j.fertnstert.2006.02.095 PMID: 16831436 ISSN: 0015-0282