Estradiol Increases Platelet Aggregation in Pl^A1/A1 Individuals

Creator(s)

Konstantinos Boudoulas, Dorothy M. Davis Heart and Lung Research Institute
Christine Roos Montague, Dorothy M. Davis Heart and Lung Research Institute
Pascal J. Goldschmidt-Clermont, Duke University Medical Center
Glen E. Cooke, Dorothy M. Davis Heart and Lung Research Institute

Document Type

Article

Publication Date

7-1-2006

Description

Background: The platelet glycoprotein IIb/IIIa receptor is a key mediator of platelet aggregation and intracoronary thrombosis. Studies have suggested that hormone replacement therapy (HRT) may increase coronary events in postmenopausal women. Objectives: We sought to characterize the relationship between the estrogen concentration expected in HRT and platelet aggregation. Design and Results: Platelet aggregation studies were performed using epinephrine on 30 healthy individuals (15 PlA1/A1 and 15 PlA1/A2) before and after incubation with β-estradiol (E2) (10-11 mol/L). The effect of E2 10-11 mol/L on PlA1/A1 platelets demonstrated a significant increase (P = .03) in aggregation compared with baseline. In contrast, with the same concentration of E2, aggregation of PlA1/A2 platelets decreased significantly compared with baseline (P < .0001). Conclusions: Estrogen concentration similar to that expected in HRT resulted in an increase in platelet aggregation in PlA1/A1 individuals, but not in PlA1/A2 individuals. The data may provide further insight for the increase in coronary events seen in HRT clinical trials and suggest that further evaluation is needed to better define the role of pharmacogenetics in HRT.

Citation Information

Boudoulas, Konstantinos; Montague, Christine Roos; Goldschmidt-Clermont, Pascal J.; and Cooke, Glen E.. 2006. Estradiol Increases Platelet Aggregation in Pl^A1/A1 Individuals. American Heart Journal. Vol.152(1). 136-139. https://doi.org/10.1016/j.ahj.2005.07.036 PMID: 16824843 ISSN: 0002-8703