Osteopontin: A Novel Inflammatory Mediator of Cardiovascular Disease
Document Type
Article
Publication Date
6-7-2007
Description
Osteopontin, also called cytokine Eta-1, is a multifunctional protein containing Arg-Gly-Asp-Ser (RODS) cell-binding sequence. It interacts with αvβ1, αvβ3 and αvβ5 integrins and CD44 receptors. OPN is suggested to play a role during inflammation via the recruitment and retention of macrophages and T-cells to inflamed sites. OPN regulates the production of inflammatory cytokines and nitric oxide in macrophages. In this review, we will discuss diverse roles of OPN related to cardiovascular diseases, including atherosclerosis, valvular stenosis, hypertrophy, myocardial infarction and heart failure.
Citation Information
Singh, Mahipal; Ananthula, Srinivas; Milhorn, Denise M.; Krishnaswamy, Guha; and Singh, Krishna. 2007. Osteopontin: A Novel Inflammatory Mediator of Cardiovascular Disease. Frontiers in Bioscience. Vol.12(1). 214-221. https://doi.org/10.2741/2059 PMID: 17127294 ISSN: 1093-9946