Retapamulin Inhibition of Translation and 50S Ribosomal Subunit Formation in Staphylococcus aureus Cells
Document Type
Article
Publication Date
9-1-2007
Description
Retapamulin inhibited protein biosynthesis and cell viability in methicillin-sensitive and methicillin-resistant Staphylococcus aureus organisms. A specific inhibitory effect on 50S ribosomal subunit formation was also found. Pulse-chase labeling experiments confirmed the specific inhibition of 50S subunit biogenesis. Turnover of 23S rRNA was found, with no effect on 16S rRNA amounts.
Citation Information
Champney, W. Scott; and Rodgers, Ward K.. 2007. Retapamulin Inhibition of Translation and 50S Ribosomal Subunit Formation in Staphylococcus aureus Cells. Antimicrobial Agents and Chemotherapy. Vol.51(9). 3385-3387. https://doi.org/10.1128/AAC.00475-07 PMID: 17562806 ISSN: 0066-4804