Facile Synthesis of Anticancer Drug NCX 4040 in Mild Conditions
Document Type
Article
Publication Date
10-1-2008
Description
A simple method is reported to synthesize an anticancer drug, NCX 4040, conveniently in mild conditions using silicon chemistry. A starting material, 4-hydroxybenzyl alcohol, was silylated selectively first to give t-butyldimethylsilyl 4-hydroxybenzyl ether, which was then converted to NCX 4040 by esterification, desilylation, hydrochlorination and nitration.
Citation Information
Xiao, Mei; Yang, Hongsong; Klein, Suzane M.; Muenyi, Christian M.; Stone, William L.; and Jiang, Yu L.. 2008. Facile Synthesis of Anticancer Drug NCX 4040 in Mild Conditions. Letters in Organic Chemistry. Vol.5(7). 510-513. https://doi.org/10.2174/157017808785982257 ISSN: 1570-1786
