Mobilization of PML-RARA Negative Blood Stem Cells and Salvage With Autologous Peripheral Blood Stem Cell Transplantation in Children With Relapsed Acute Promyelocyte Leukemia
Document Type
Article
Publication Date
10-1-2008
Description
Background. Relapsed acute promyleocytic leukemia (APL) is treated with re-induction chemotherapy, commonly arsenic trioxide, and stem cell transplantation (SCT). The effect of arsenic trioxide on autologous peripheral blood stem cell collection is unknown. Procedure. Five pediatric patients with relapsed APL had PML-RARA negative peripheral blood stem cells mobilized (four after arsenic trioxide) and underwent autologous SCT after cyclophosphamide (60 mg/kg x 2) and total body irradiation (TBI-fractionated 1,200 cGy) conditioning. Results. All five patients remain in molecular remission a median of 20 months post-transplant. Conclusion. Autologous SCT performed during molecular remission is a treatment option for pediatric patients with relapsed APL and may provide durable leukemia-free survival without the complications of allogeneic transplantation.
Citation Information
Termuhlen, Amanda; Klopfenstein, Kathryn; Olshefski, Randall; Rosselet, Robin; Yeager, Nicholas D.; Soni, Sandeep; and Gross, Thomas G.. 2008. Mobilization of PML-RARA Negative Blood Stem Cells and Salvage With Autologous Peripheral Blood Stem Cell Transplantation in Children With Relapsed Acute Promyelocyte Leukemia. Pediatric Blood and Cancer. Vol.51(4). 521-524. https://doi.org/10.1002/pbc.21614 PMID: 18493994 ISSN: 1545-5009