Spongiform Encephalopathy Following Allogeneic Cord Blood Transplant
Document Type
Article
Publication Date
2-1-2008
Description
A 6 year old boy developed a fatal, rapidly progressive encephalopathy 5 months after a matched unrelated cord blood transplant. Autopsy findings revealed spongiform changes in his brain. The clinical course of this child's illness had many findings consistent with that of a transmissible spongiform encephalopathy (TSE). Pre-mortem and post-mortem studies failed to definitively determine an etiology. Spongiform encephalopathies include the TSEs and mitochondrial encephalopathies. Both should be considered in a post-hematopoietic stem cell transplant patient who develops a progressive encephalopathy when more common etiologies are not found.
Citation Information
O'Brien, Dennis; Klopfenstein, Kathryn; Gross, Thomas G.; Baker, Peter; and Termuhlen, Amanda. 2008. Spongiform Encephalopathy Following Allogeneic Cord Blood Transplant. Pediatric Transplantation. Vol.12(1). 95-98. https://doi.org/10.1111/j.1399-3046.2007.00828.x PMID: 18186895 ISSN: 1397-3142