Restraint Stress Induces Lymphocyte Reduction Through p53 and PI3K/NF-κB Pathways
Document Type
Article
Publication Date
8-30-2008
Description
Restraint stress, either physical or psychological, can modulate immune function. However, the mechanisms associated with stress-induced lymphocyte reduction remains to be elucidated. We have previously shown that chronic stress induces Fas-mediated lymphocyte reduction. Here, we investigated the mechanisms by which restraint stress modulates lymphocyte reduction. Our data have shown that inhibition of p53 by the p53 inhibitor PFT-α attenuates stress-induced reduction in lymphocyte numbers. These results were verified using p53 knockout mice, suggesting a pivotal role of p53 in this process. In addition our data have indicated that PI3K/nuclear factor kappa B (NF-κB) signaling pathway plays an important role in the stress-induced lymphocyte reduction. Our study thus demonstrates that restraint stress promotes lymphocyte reduction through p53 and PI3K/NF-κB pathways.
Citation Information
Zhang, Yi; Foster, Robert; Sun, Xiuli; Yin, Qiaoqiao; Li, Yi; Hanley, Gregory; Stuart, Charles; Gan, Yili; Li, Chuanfu; Zhang, Zhiyong; and Yin, Deling. 2008. Restraint Stress Induces Lymphocyte Reduction Through p53 and PI3K/NF-κB Pathways. Journal of Neuroimmunology. Vol.200(1-2). 71-76. https://doi.org/10.1016/j.jneuroim.2008.06.014 PMID: 18653242 ISSN: 0165-5728