Convenient Preparation of 2,7,8-Trimethyl-6-Hydroxychroman-2-Carboxylic Acid (γ-Trolox)
Document Type
Article
Publication Date
1-1-2008
Description
The title chroman is useful in synthesis and as a water-soluble analog of γ-tocopherol, a member of the vitamin E family. This new synthesis of γ-trolox proceeds via selective aromatic demethylation of Trolox, the more easily available 2,5,7,8-tetramethyl homolog compound. This route is shorter than the previous synthesis, avoids the use of cyanide and methoxybutadiene, and requires no chromatography.
Citation Information
Hyatt, John. 2008. Convenient Preparation of 2,7,8-Trimethyl-6-Hydroxychroman-2-Carboxylic Acid (γ-Trolox). Synthetic Communications. Vol.38(1). 8-14. https://doi.org/10.1080/00397910701648728 ISSN: 0039-7911