Effects of Memantine on Cerebrospinal Fluid Biomarkers of Neurofibrillary Pathology
Document Type
Article
Publication Date
1-1-2009
Description
Previous studies showed that memantine inhibits tau hyperphosphorylation in vitro. In this study, phosphorylated tau (P-tau) and total tau (T-tau) were measured before and after 6 month treatment with memantine in 12 subjects ranging from normal cognition with subjective memory complaints, through mild cognitive impairment to mild Alzheimer's disease. Thirteen non-treated individuals served as controls. Treatment was associated with a reduction of P-tau in subjects with normal cognition. No treatment effects were seen among impaired individuals, suggesting that longer treatment time may be necessary to achieve biomarker effect in this group.
Citation Information
Glodzik, Lidia; De Santi, Susan; Rich, Kenneth E.; Brys, Miroslaw; Pirraglia, Elizabeth; Mistur, Rachel; Switalski, Remigiusz; Mosconi, Lisa; Sadowski, Martin; Zetterberg, Henrik; Blennow, Kaj; and De Leon, Mony J.. 2009. Effects of Memantine on Cerebrospinal Fluid Biomarkers of Neurofibrillary Pathology. Journal of Alzheimer's Disease. Vol.18(3). 509-513. https://doi.org/10.3233/JAD-2009-1183 ISSN: 1387-2877