Title
Risk Factors for Thrombosis in Cancer Patients
Document Type
Review
Publication Date
5-6-2009
Description
Venous thromboembolism (VTE), comprised of deep vein thrombosis (DVT) and its complication, pulmonary embolism (PE), is a multifactorial disease, involving complex interactions between environmental exposures and patients, including their hemostatic system and genetic predispositions. VTE is relatively common, with an overall average age- and sex-adjusted incidence of about 1.04-1.9 per 1000 person-years that rises dramatically with increasing age [1-4]. Active malignancy accounts for almost 20% of incident VTE events occurring in the community [5], and imparts a 4- to 6.5-fold higher VTE risk compared to non-cancer patients, depending on concurrent use of anti-cancer therapy [6]. The risk of VTE also varies by cancer type and stage [7-10]. The association between VTE and malignancy has been recognized since 1861 when Trousseau, in a lecture, described thrombophlebitis as the presenting sign of visceral malignancy [11].
Citation Information
Ashrani, Aneel A.; and Heit, John A.. 2009. Risk Factors for Thrombosis in Cancer Patients. Cancer Treatment and Research. Vol.148 95-114. https://doi.org/10.1007/978-0-387-79962-9_7 PMID: 19377921 ISSN: 0927-3042 ISBN: 9780387799612