Internalization of Dectin-1 Terminates Induction of Inflammatory Responses
Document Type
Article
Publication Date
6-25-2009
Description
Dectin-1 is a pattern-recognition receptor recognizing β-(1,3)-glucans found on fungal cell walls. Dectin-1 plays an important role in immunity to fungi by mediating phagocytic clearance of fungal particles and inducing transcription of innate response genes. We show here that the two processes are linked and that Dectin-1 signalling for inflammation is attenuated by phagocytosis. Blocking Dectin-1 ligand-dependent internalization using either actin polymerization or dynamin inhibitors, large non-phagocytosable β-glucan particles or poorly phagocytic cells leads in all cases to enhanced and sustained activation of downstream signalling pathways and culminates in production of high levels of proinflammatory cytokines. These findings establish the importance of phagocytosis not only in the clearance of pathogens, but also in the modulation of pattern-recognition receptor signalling and strongly suggest that internalization is the first step to attenuation of Dectin-1-mediated pro-inflammatory responses.
Citation Information
Hernanz-Falcón, Patricia; Joffre, Olivier; Williams, David L.; and Reis e Sousa, Caetano. 2009. Internalization of Dectin-1 Terminates Induction of Inflammatory Responses. European Journal of Immunology. Vol.39(2). 507-513. https://doi.org/10.1002/eji.200838687 PMID: 19130473 ISSN: 0014-2980